What is Aptamil Pepti SYNEO?
Aptamil Pepti SYNEO is a specialised European infant formula for babies from birth with a diagnosed or strongly suspected cow's milk protein allergy (CMPA). Its whey protein is extensively hydrolysed, and it adds the SYNEO synbiotic — a GOS/FOS prebiotic combined with the probiotic strain Bifidobacterium breve M-16V. This listing is a 400 g box, roughly 90 fl oz of prepared formula.
This is a clinical product, not a consumer upgrade. Aptamil is made by Nutricia, Danone's clinical nutrition division, and in the UK Pepti SYNEO is ACBS-approved and prescribable on FP10 for the dietary management of cow's milk allergy. If nobody has diagnosed your baby yet, the right next step is your paediatrician or an allergy dietitian, not a different tin.
What SYNEO actually adds is worth being precise about, because the name is doing a lot of work on the packaging. SYNEO is a synbiotic: a prebiotic and a probiotic supplied together. The prebiotic is the same galacto- and fructo-oligosaccharide blend used across the Pepti range. The probiotic is a specific named strain, Bifidobacterium breve M-16V, which plain Aptamil Pepti 1 and 2 do not contain. The hydrolysis level is unchanged — SYNEO is not "more hypoallergenic" than plain Pepti, it is plain Pepti's hydrolysis plus a live culture.
Where it sits in the feeding journey: Pepti SYNEO can be a baby's sole source of nutrition from birth to six months and continue as part of a balanced diet from six months onward. Parents usually arrive here because a clinician wants gut-microbiome support alongside standard allergy management. Breastfeeding, where possible, remains the first option, and a maternal dairy-free diet is often trialled before any formula change.
From birthSole nutrition to 6 months
400 gSingle box
~90 fl oz≈ 18 × 5 oz bottles (est.)
SynbioticGOS/FOS + B. breve M-16V
The yield figure is our own calculation from a scoop weight assumed by analogy to the rest of the Pepti range, not a manufacturer-published number for this box. Treat it as a planning estimate.
What's in Aptamil Pepti SYNEO?
Aptamil Pepti SYNEO is built on extensively hydrolysed whey protein from cow's milk, with maltodextrin, a vegetable oil blend of palm, coconut, rapeseed and high oleic sunflower oils, galacto-oligosaccharides and fructo-oligosaccharides, fish oil, and the live probiotic strain Bifidobacterium breve M-16V. It carries DHA and the vitamins and minerals an infant formula must contain. The declared allergens are milk and fish.
| What's inside | Aptamil Pepti SYNEO |
|---|---|
| Protein source | Whey protein hydrolysate, from cow's milk |
| Degree of hydrolysis | Extensive — the same tier as Pepti 1 and 2 |
| Prebiotic | Galacto- and fructo-oligosaccharides (GOS/FOS) |
| Probiotic | Bifidobacterium breve M-16V |
| Carbohydrate | Maltodextrin |
| Fats | Palm, coconut, rapeseed, high oleic sunflower, fish oil |
| DHA | Yes |
| Allergens | Milk, fish |
- Extensively hydrolysed whey
- GOS/FOS prebiotic blend
- Live B. breve M-16V
- DHA and omega fats
- Full vitamin and mineral spread
- Nutritionally complete from birth
We do not publish a per-100ml energy, fat, protein and carbohydrate panel for Pepti SYNEO here, because the source material we hold for this box does not carry one. The panel printed on your own box is the figure to work from.
What does SYNEO mean in Aptamil Pepti SYNEO?
SYNEO is Nutricia's name for a synbiotic — a prebiotic and a probiotic delivered together in the same formula. In Aptamil Pepti SYNEO the prebiotic is the GOS/FOS oligosaccharide blend used across the Pepti range, and the probiotic is the specific live strain Bifidobacterium breve M-16V.
A prebiotic is food for bacteria; a probiotic is the bacteria. Supplying both is the reason for the word synbiotic, and it is a genuine formulation difference rather than a marketing flourish: plain Aptamil Pepti 1 and Pepti 2 contain the prebiotic but no live probiotic strain at all. The clinical rationale Nutricia gives is combined support for the gut microbiome in infants managing cow's milk allergy.
What SYNEO does not change is the allergy protection. The protein hydrolysis in this box is extensive, exactly as it is in plain Pepti — not deeper, not more hypoallergenic. If your clinician has put your baby on plain Pepti, moving to SYNEO is a decision about gut support, not about allergen exposure. Ask them whether it is worth the change for your baby before you switch on your own.
Prebiotic · GOS and FOS
Probiotic · Bifidobacterium breve M-16V
Prebiotic plus probiotic together is what the word synbiotic means. Plain Aptamil Pepti carries the prebiotic alone; SYNEO adds the named live strain on top of it.
Pepti SYNEO
Plain Aptamil Pepti
Schematic illustrations of the ingredients described, not to scale and not microscopy. We describe what the synbiotic contains; we make no claim about clinical outcomes beyond the manufacturer's own positioning.
What is not in Aptamil Pepti SYNEO — and what is?
Aptamil Pepti SYNEO is a clinical formula rather than a clean-label one, and we would rather set that out plainly than let the word "gentle" do work it has not earned. It contains no intact cow's milk protein and no casein. It does contain palm oil, fish oil and maltodextrin, and it is not organic certified — EU rules do not permit an organic claim on extensively hydrolysed protein.
| In this box | Aptamil Pepti SYNEO |
|---|---|
| Intact cow's milk protein | None — extensively hydrolysed whey |
| Prebiotic | Yes — GOS and FOS |
| Probiotic strain | Yes — Bifidobacterium breve M-16V |
| Palm oil | Yes, in the vegetable oil blend |
| Fish oil | Yes — an omega-3 source |
| Maltodextrin | Yes — the carbohydrate source |
| Organic certified | No |
| Halal or kosher | See product page |
| Allergens | Milk, fish |
Halal and kosher status are not confirmed for this box in the material we hold, so we make no claim either way. The Pepti range is produced using a trypsin enzyme of porcine origin during hydrolysis; the enzyme is not present in the finished powder, but if this matters to your family, ask us before you order.
How does Aptamil Pepti SYNEO compare to Aptamil Pepti 1 and Aptamil Pepti MCT?
All three are extensively hydrolysed formulas from the same range and from birth. Pepti 1 is the standard choice for a diagnosed cow's milk allergy. Pepti SYNEO is the same indication with an added live probiotic strain. Pepti MCT is a different problem entirely — it is for babies whose gut cannot absorb ordinary fat.
| Specialised Aptamil | Aptamil Pepti SYNEO | Aptamil Pepti 1 | Aptamil Pepti MCT |
|---|---|---|---|
| What it is for | Diagnosed or suspected CMPA | Diagnosed or suspected CMPA | Malabsorption-related conditions |
| Hydrolysis | Extensive | Extensive | Extensive |
| Probiotic strain | Bifidobacterium breve M-16V | None | None |
| Prebiotic | GOS/FOS | GOS/FOS 9:1 | See product page |
| MCT fat | Not an MCT formula | Not an MCT formula | Yes — 50% of total fat |
| Protein per 100ml | See product page | 1.6 g | 1.8 g |
| Carbohydrate | Maltodextrin | Maltodextrin | Glucose syrup, maltodextrin |
| Organic certified | No | No | No |
| Age | From birth | From birth | From birth |
| Pack size | 400 g | 800 g | 450 g |
Being straight with you: check the pack sizes before you compare prices, because they do not match — 400 g here, 800 g for Pepti 1, 450 g for Pepti MCT. The shelf price of this box looks lower than Pepti 1's largely because it holds half as much powder. Compare price per prepared fluid ounce instead, and on that measure Aptamil Pepti 1 in its 800 g box will almost always come out cheaper per feed than this one, for the same extensive hydrolysis and the same allergy indication. The probiotic strain is what you are paying extra for. That is a real difference, but whether your baby benefits from it is a question for your dietitian, not for a product page. And if the problem is fat absorption rather than allergy, neither of these is the right formula — Aptamil Pepti MCT is.
How many boxes of Aptamil Pepti SYNEO will my baby need per month?
An exclusively formula-fed baby on the Aptamil Pepti range uses roughly 8 to 10 boxes of this 400 g size per month. One 400 g box makes approximately 90 fl oz of prepared formula, or about 18 bottles of 5 fl oz — which is why this smaller pack empties quickly if it is your baby's only feed.
That range is an estimate carried across from the wider Pepti range rather than a figure published for Pepti SYNEO itself, so treat it as orientation. Babies with cow's milk allergy are often on a feeding volume set by a dietitian rather than by appetite alone, and any breastfeeding alongside the formula pulls the number down. If your care team has given you a daily volume in millilitres, work from that instead.
Estimates carried across from the wider Aptamil Pepti range, not published for this box specifically. Every baby feeds differently — use these for planning, not as a target.
How do you prepare Aptamil Pepti SYNEO?
Sterilise the bottle, boil fresh water and let it cool to room temperature, pour the measured water into the bottle first, then add one level scoop for every 30ml of water, shake for about 25 seconds until fully dissolved, and feed straight away. This formula is the exception in our range — it is not mixed with hot water, because the live culture would not survive it.
Room tempCool the water fully first
1 : 30mlOne level scoop per 30ml
~25 secShake until dissolved
Feed freshDiscard unused formula
1
Sterilise everything
Wash and sterilise the bottle, teat, ring and cap, and wash your hands before you start.
2
Boil, then cool fully
Boil fresh water, pour it into the sterilised bottle, cap it, and let it cool to room temperature before any powder goes in.
3
Water into the bottle first
Pour the measured water into the sterilised bottle before you add any powder — never the other way round.
4
Add level scoops
Add one level scoop for every 30ml of water, using only the scoop in this box and never packing or heaping it.
5
Cap and shake
Cap the bottle and shake vigorously for about 25 seconds until the powder has completely dissolved.
6
Test and feed
Test a drop on the inside of your wrist, then feed straight away. Made with room-temperature water the bottle should already be close to right, so it normally needs no cooling.
Never use artificially softened water or water that has been boiled more than once. Never add an extra scoop or change the dilution unless a dietitian has told you to. Make a fresh bottle for every feed, never reheat, never microwave, and discard unused formula within the window stated on your box rather than saving it.
A note on water temperature — read this one, it differs from every other formula we sell. Nutricia's own instructions for Pepti SYNEO are to boil fresh water, pour it into the sterilised bottle, cap it and let it cool to room temperature before the powder goes in. That is deliberate, and it is not the 70 °C water used for ordinary powdered formula. The reason is the live Bifidobacterium breve M-16V: hot water kills it, and Nutricia states that warming and incorrect preparation can limit its benefits.
You may have read different advice. The World Health Organization and the UK's NHS advise water at 70°C or hotter for any powdered formula, because powder is not sterile. In the United States the FDA and CDC take a narrower position: they advise water of at least 158°F (70°C) when a baby is under 2 months old, born prematurely, or has a weakened immune system, and say that for most other babies, preparing formula according to the manufacturer's instructions is considered safe.
Because room-temperature water does not kill bacteria that can occasionally be present in powder, hygiene matters more here rather than less — sterilise everything, make each bottle fresh, feed it straight away, and never let a made-up bottle stand. Always test a drop on the inside of your wrist before feeding. If your baby is in one of the higher-risk groups above, or your dietitian has given you different instructions, follow theirs.
A note on water temperature — read this one, it differs from every other formula we sell. Nutricia's own instructions for Pepti SYNEO are to boil fresh water, pour it into the sterilised bottle, cap it and let it cool to room temperature before the powder goes in. That is deliberate, and it is not the 70 °C water used for ordinary powdered formula. The reason is the live Bifidobacterium breve M-16V: hot water kills it, and Nutricia states that warming and incorrect preparation can limit its benefits.
You may have read different advice. The World Health Organization and the UK's NHS advise water at 70°C or hotter for any powdered formula, because powder is not sterile. In the United States the FDA and CDC take a narrower position: they advise water of at least 158°F (70°C) when a baby is under 2 months old, born prematurely, or has a weakened immune system, and say that for most other babies, preparing formula according to the manufacturer's instructions is considered safe.
Because room-temperature water does not kill bacteria that can occasionally be present in powder, hygiene matters more here rather than less — sterilise everything, make each bottle fresh, feed it straight away, and never let a made-up bottle stand. Always test a drop on the inside of your wrist before feeding. If your baby is in one of the higher-risk groups above, or your dietitian has given you different instructions, follow theirs.
Please read before buying
Aptamil Pepti SYNEO is a specialised formula for the dietary management of diagnosed cow's milk protein allergy, intended to be used under medical supervision. It is not a general-purpose sensitive-tummy milk and it is not a product to switch to on your own. If you think your baby is reacting to milk, see your doctor or an allergy dietitian for a diagnosis and a feeding plan first. Contains milk and fish. Breastfeeding is best for your baby — talk to your health visitor or doctor before starting or changing a formula.
Store boxes in a cool, dry place. Once opened, use within the period stated on the pack. Never reheat or microwave prepared formula.
Taste & smell
Extensively hydrolysed formula smells and tastes stronger, more savoury and more bitter than standard milk. That is the hydrolysis, not spoilage. If your baby resists the switch, most dietitians suggest introducing it gradually over several days rather than all at once.
Aptamil Pepti SYNEO: frequently asked questions
What age is Aptamil Pepti SYNEO for?
Aptamil Pepti SYNEO is for babies from birth. It can be a baby's sole source of nutrition up to six months and can continue as part of a balanced diet from six months onward. How long a baby stays on an extensively hydrolysed formula, and when to trial ordinary milk protein again, is a decision for your paediatrician or allergy dietitian rather than the box.
What does SYNEO mean?
SYNEO is Nutricia's name for a synbiotic, which means a prebiotic and a probiotic supplied together. In this formula the prebiotic is the galacto- and fructo-oligosaccharide blend used across the Aptamil Pepti range, and the probiotic is the live strain Bifidobacterium breve M-16V. Plain Aptamil Pepti 1 and Pepti 2 contain the prebiotic but no live probiotic strain.
Is Pepti SYNEO more hypoallergenic than plain Aptamil Pepti?
No. The degree of protein hydrolysis is the same in both — extensive. SYNEO changes what the formula carries for the gut microbiome, not how far the milk protein has been broken down. If a clinician has your baby on plain Pepti and it is working, switching to SYNEO is a question about gut support, not about better allergy protection.
Can I buy Aptamil Pepti SYNEO without a prescription?
In the United States you can buy it as a food product, which is what this listing is. In the United Kingdom it is ACBS-approved and doctors prescribe it on FP10. Either way it is designed to be used under medical supervision, because a cow's milk protein allergy needs to be diagnosed, monitored and eventually re-tested by a clinician rather than managed from a shop shelf.
Is Aptamil Pepti SYNEO organic?
No. Aptamil Pepti SYNEO carries no organic certification and is not eligible for one — EU organic rules do not permit an organic claim on extensively hydrolysed protein. Aptamil's strength here is clinical formulation and a long record in hospital paediatric dietetics, not a certification story. No extensively hydrolysed allergy formula from any brand carries an organic label.
How much prepared formula does one 400 g box make?
One 400 g box makes approximately 90 fluid ounces of prepared formula, which is roughly 18 bottles of 5 fl oz. That figure is our own calculation from a scoop weight assumed by analogy to the rest of the Pepti range rather than a manufacturer-published number for this box, so treat it as an estimate and check the feed table printed on your own box.
Why does Aptamil Pepti SYNEO smell and taste so strong?
Because the whey protein has been broken down extensively by enzymes, which releases bitter and savoury-tasting peptides. Every extensively hydrolysed formula shares this, regardless of brand, and it is not a sign the powder has spoiled. Younger babies usually accept it quickly; older babies often do better if the new formula is mixed in gradually over several days.
Related formulas at Bonpek Baby
- Aptamil Pepti 1The same hydrolysis without the probiotic, in a larger 800 g box.
- Aptamil Pepti 2The 6 months+ stage in the extensively hydrolysed range.
- Aptamil Pepti MCTFor babies with fat malabsorption, on a clinician's direction.
- Aptamil HA 1Partially hydrolysed, for allergy risk reduction — not for a diagnosed allergy.
- Aptamil AR 400 gThickened anti-reflux formula, if frequent spit-up is the problem.
- All baby formulasBrowse every European formula we stock, by brand and stage.
Why parents buy from Bonpek Baby
- Authentic from Europe for 8+ years
- US stock — no shipping or customs delays
- Same-day pickup & delivery for locals
- Always fresh — receiving weekly
- Best prices, or we'll match and add a free gift
- Trusted by 9,000+ parents in the US
- Prompt customer support text line
Product information last reviewed by the Bonpek Baby team in September 2026 against the manufacturer's current published ingredient and nutrition data. Always check the label on your box, as manufacturers reformulate from time to time.
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